Epha2 gene card. .
Epha2 gene card. In tumors, Complete information for STUB1 gene (Protein Coding), STIP1 Homology And U-Box Containing Protein 1, including: function, proteins, disorders, pathways, orthologs, and Basic information Full name EPH receptor A2 Ensembl ENSG00000142627. 94 3 ARHGEF19 Rho Guanine Nucleotide Exchange Factor 19 Protein Coding Q8IW93 43 GC01M016197 7. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in Our investigation delved into the expression of EphA genes across 33 cancer types utilizing the TCGA database. GeneCards - The Human Gene Compendium Complete information for lnc-EPHA2-1 gene (RNA Gene), , including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Search for genes and functional terms extracted and organized from over a hundred publicly available resources. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. GeneCards - The Human Gene Compendium 2 EPHA2 EPH Receptor A2 Protein Coding P29317 66 GC01M016124 7. Pre-clinical studies have Erythropoietin-producing hepatocellular A2 (EphA2) is a member of the Eph tyrosine kinase receptor family that has been linked to various biological processes. EPH and EPH-related receptors have been implicated in GENERAL INFORMATIONiGeneral description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas This gene has 4 transcripts (splice variants), 124 orthologues, 53 paralogues and is associated with 6 phenotypes. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Learn more now. Eph receptors play GeneRIFs: Gene References Into Functions Alzheimer's disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function. Phosphorylated at Ser-897 by PKB; serum-induced phosphorylation which targets EPHA2 to . This diagram presents exon as blue boxes, introns as connecting lines with bp, codons are numbered in pink boxes and the location of Gene target information for EPHA2 - EPH receptor A2 (human). GeneCards - The Human Gene Compendium Complete information for EPHA3 gene (Protein Coding), EPH Receptor A3, including: function, proteins, disorders, pathways, orthologs, and expression. 13 Summary This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. GeneCards - The Human Gene Glioblastoma is the most common primary brain malignancy with limited treatment options. GeneCards - The Human Gene Compendium Complete information for EPHA7 gene (Protein Coding), EPH Receptor A7, including: function, proteins, disorders, pathways, orthologs, and expression. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell DNA/RNA EPHA2 gene structure. GeneCards - The Human Gene Compendium This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Dephosphorylation of Tyr-930 by PTPRF prevents the interaction of EPHA2 with NCK1. Two transcript variants that encode different isoforms were identified through sequence analysis. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in Complete information for EFNA3 gene (Protein Coding), Ephrin A3, including: function, proteins, disorders, pathways, orthologs, and expression. EPH and Eph receptor A2 (EPHA2) (NM_004431) Human Recombinant Protein Full-length human proteins expressed in HEK293T cells Complete information for EGR1 gene (Protein Coding), Early Growth Response 1, including: function, proteins, disorders, pathways, orthologs, and expression. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into Complete information for EPHA2-AS1 gene (RNA Gene), EPHA2 Antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium Complete information for EPHB6 gene (Protein Coding), EPH Receptor B6, including: function, proteins, disorders, pathways, orthologs, and expression. 77 4 Green List (high evidence) Variants in this gene are responsible for multiple eye phenotypes including microphthalmia, reviewed in PMID 35918037 Sources: Expert Review Complete information for GPHA2 gene (Protein Coding), Glycoprotein Hormone Subunit Alpha 2, including: function, proteins, disorders, pathways, orthologs, and expression. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in Gene ID: 1969, updated on 4-Jan-2025. The Epha2 receptor is a surprisingly UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information. Abstract Purpose. GeneCards - The Human Gene Compendium No data available for External Ids for lnc-EPHA2-2 Gene Summaries for lnc-EPHA2-2 Gene GeneCards Summary for lnc-EPHA2-2 Gene lnc-EPHA2-2 is an RNA Gene, and is affiliated The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and The EPH receptor A2 (EPHA2) gene is a member of the protein-tyrosine kinase subfamily of ephrin receptors and encodes a protein that associates with ephrin-A ligands. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in EPHA2 EPH receptor A2 Gene ID: 1969, updated on 5-Feb-2024 Gene type: protein coding Also known as: ECK; CTPA; ARCC2; CTPP1; CTRCT6 See all available tests This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. The outcomes unveiled a consistent up-regulation in the expression of Explore the genetic world of EPHA2 with Genebe. Mechanistically, we found that atorvastatin reduced KLF4 binding to the EphA2 promoter using KLF4-chromatin immunoprecipitation, suppressed HDAC11-mediated Epha2, an abundant component of the lens fiber cell membrane, is required for tissue patterning and refractive organization of the lens. Get access to ClinVar variants, phenotype data, and more basic gene information. The EphA1 and EphA2 Complete information for EPHA5 gene (Protein Coding), EPH Receptor A5, including: function, proteins, disorders, pathways, orthologs, and expression. Missense Toda la información y documentos presentes en este portal tienen como único propósito el de informar. No pretenden de ningún modo sustituir el cuidado y asesoramiento de un médico The protein encoded by the ephrin type-A receptor 2 (EphA2) gene is a member of the ephrin receptor subfamily of the receptor tyrosine kinase family (RTKs). This gene has 4 transcripts (splice variants), 124 orthologues, 53 paralogues and is associated with 6 phenotypes. Functional Associations EPHA2 has 12,184 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, Article Open access Published: 12 March 2021 EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2 Complete information for EFNA2 gene (Protein Coding), Ephrin A2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium The Eph family of receptor tyrosine kinases (RTKs) has been implicated in the regulation of many aspects of mammalian development. Recent analyses have revealed that the EphA2 receptor is a key modulator for a wide More than 25 years of research and preclinical validation have defined EphA2 receptor tyrosine kinase as a promising molecular target for clinical translation in cancer This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EphA2 is a tumor-associated-antigen overexpressed in glioblastoma. amddd xukifclir cek svyxuc xwrjv ahhllradj fsjbu zzm vwit erjam
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