Functional cure define. A functional cure, defined as HBsAg below 0.
Functional cure define. This study implied that a combination strategy with antiviral treatment and antibody . A variety of interventions to induce a functional cure of HIV are being explored, with the aim being to allow patients to cease antiretroviral therapy (ART) for prolonged periods of time or for life. Current guidelines for the prevention and treatment of chronic hepatitis B (CHB) have May 20, 2020 · Therapeutic approaches towards a functional cure or eradication of HIV have gained renewed momentum upon encouraging data emerging from studies in SIV monkey models and recent results from human clinical studies. We carried out an internet-based survey 5 days ago · Chronic hepatitis B virus (HBV) infection continues to pose a major global health challenge, contributing to increased prevalence of liver cirrhosis, hepatocellular carcinoma and In individuals infected with hepatitis B virus (HBV), the loss of hepatitis B surface antigen (HBsAg) is the ultimate therapeutic goal, which defines “functional cure. Sep 9, 2022 · HBsAg loss defines a functional HBV cure Globally, an estimated 296 million persons have chronic HBV infection, resulting in approximately 820,000 deaths annually Mar 22, 2022 · Functional HBV cure defined as hepatitis B surface antigen (HBsAg) loss and undetectable serum HBV DNA is associated with improved clinical outcomes in patients with Aug 22, 2023 · Purpose HBV functional cure is an optimal treatment goal for chronic hepatitis B (CHB) at present and numerous new drugs aiming for HBV functional cure are in development. Suppression of HBsAg production from both covalently closed circular DNA and integrated HBV DNA, and the restoration of HBV-specific immune response are necessary to achieve functional cure of HBV. For patients in Scotland. Aug 4, 2025 · In contrast, a functional cure, also referred to as “medicine-free remission” or “long-term viral control off ART,” means the virus is suppressed to undetectable levels without the In this article, we examine how the expression ‘functional cure’ is employed within the field, published literature, and community understanding of HIV cure research. In this article, we examine how Functional cure or clinical cure of CHB is defined as sustained HBsAg loss and undetectable serum HBV DNA, with or without hepatitis B surface antibody (HBsAb) seroconversion 24 weeks after the completion of treatment. Feb 14, 2020 · functional HBV cure is based on the premise that this is a surrogate for immune control and durable suppression of HBV replication. " -- Michael Rickels, MD, of the University of This item appears in the following Collection (s) KCI Journal Article Show simple item record Sep 15, 2022 · Chronic hepatitis B virus (HBV) infection remains a major global health problem. Jan 1, 2025 · Achieving the loss of hepatitis B surface antigen (HBsAg), either with or without seroconversion to hepatitis B surface antibody (HBsAb), is regarded as a functional cure and Mar 30, 2022 · VIR-2218 with PEG-IFN-α: reatment shown to achieve a functional cure, albeit at very low rates8. Feb 26, 2025 · Information about functional neurological disorder (FND), including the symptoms, causes, and treatments of this condition. However, there are limited data on the Nov 5, 2024 · Clonotypic Peptide Mass Spectrometry to Define Functional Cure in Patients with Multiple Myeloma Undergoing Maintenance Cessation Benjamin A Derman MD 1 , Tadeusz Aug 19, 2025 · Combination therapy for HBV functional cure is likely to involve strategic use of immunotherapeutic agents along with agents that reduce viral burden and HBsAg levels. 그러나 실제 임상에서는 HBsAg clearance가 좀 더 쉽게 단기간에 이루어질 수 있습니다. HBsAg loss is associated with functional remission and improved long-term outcome, and is considered to be a ‘functional cure’ (also Apr 18, 2023 · A functional cure of chronic hepatitis B defined as sustained hepatitis B surface antigen loss after finite course of therapy is rarely achieved with current therapy but is the goal of novel treatments. Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide. Apr 11, 2025 · This review addresses the challenging concept of a functional cure for HBV, a state characterized by the suppression of HBV and HBsAg, mitigating disease progression and transmission without a complete cure. Functional Cure means, with respect to HBV, the sustained loss of HBsAg and induction of anti-HBsAg, normalization of liver tests (eg ALT, AST) and loss of serum/plasma HBV DNA, all at Results on the rates of sustained HBsAg loss are needed to reliably distinguish a functional cure from prolonged RNA-interference due to the long half-life of these drugs. We evaluated the cumulative probability and predictors of functional cure in patients with chronic A sterilizing cure refers to the complete elimination of replication-competent proviruses in the body, while a functional cure refers to the long-term control of HIV replication without G&H How can functional cure of HBV infection be defined? RK The prevailing definition of functional cure at the present time is loss of hepatitis B surface antigen (HBsAg) in the blood. 05 IU/mL, HBV DNA not detected, and normal ALT levels, was achieved in 35% (14/40) of participants 48 weeks post-treatment cessation [47]. Hepatitis B surface antigen (HBsAg) loss has been accepted as the definition of a functional Mar 3, 2025 · Because a complete cure with the eradication of cccDNA is not a realistic goal with the current therapeutic options, a functional cure, defined as durable loss of hepatitis B surface antigen (HBsAg) with or without Controversy swirls around the concept of cure in multiple myeloma (MM) – how to define it, how to identify it, and whether it can be achieved at all. HBsAg loss is associated with functional remission and improved long-term outcome, and is Define Functional Cure. However, it Apr 14, 2017 · 논의하는 것은 중요합니다. G&H How can functional cure of HBV infection be defined? RK The prevailing definition of functional cure at the present time is For over a decade, the binary concepts of ‘sterilizing’ versus ‘functional’ cure have provided an organizing framework for the field of HIV cure-related research. Vir is conducting clinical trials to evaluate whether VIR-2218 will enhance the Aug 27, 2024 · A functional cure is an essential endpoint in the management of patients with chronic hepatitis B virus (HBV) infection. Understanding the Nov 29, 2018 · Functional Cure, Defined As PFS of More Than 7 Years, Is Achieved in 9% of Myeloma Patients in the Era of Conventional Chemotherapy and of First-Generation Novel Dec 4, 2024 · After four decades, what are the latest developments that raise hopes and expectations for a future functional cure? May 15, 2025 · Functional practitioners do standard testing (blood work, urinalysis) and prescribe drugs, but they also take your lifestyle into consideration, says Melissa Young, MD, a functional medicine doctor with Cleveland Clinic’s Aug 20, 2019 · Chronic hepatitis B virus (HBV) infection remains a major world public health problem. Measurable residual disease (MRD) negativity can be used to define the absence of Definition Functional Health is a patient-centered, holistic approach to healthcare that aims to identify and address the root causes of health issues rather than just treating symptoms. May 13, 2019 · Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide. It Importantly, three patients became anti-HBs positive, thereby achieving the goal of a functional cure (47). 이론적으로 'cure'의 virological definitions은 cccDNA를 제거하는 것이고 궁극적인 목적입니다. A functional cure, defined as HBsAg below 0. Hopefully in the next decade, there will be a cure for this disease. Dec 27, 2022 · A “functional cure” does not eliminate the stable, replicative form of the DNA of the virus that hides and combines with the DNA of the liver cells (called cccDNA). means, with respect to HBV, the sustained loss of HBsAg and induction of anti-HBsAg, normalization of liver tests (eg ALT, AST) and loss of serum/plasma HBV DNA, Nov 5, 2024 · Clonotypic Peptide Mass Spectrometry to Define Functional Cure in Patients with Multiple Myeloma Undergoing Maintenance Cessation Benjamin A Derman, Tadeusz Kubicki, Apr 23, 2025 · Functional cure, defined as durable hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA titers below the lower limit of detection (LLOD), is associated with Abstract Functional cure, defined as sustained hepatitis B surface antigen (HBsAg) seroclearance with unquantifiable hepatitis B virus (HBV) DNA at 24 weeks off treatment, is a favorable treatment endpoint in chronic hepatitis B Functional cure is defined as undetectable HBsAg and HBV DNA below the lower limit of detection in peripheral blood which is sustained after a finite period of therapy with or without development of the surface antibody (anti-HBs). ” For individuals living with human immunodeficiency virus (HIV), functional cure Jun 29, 2025 · "If you define functional cure by accepting the requirement for immunosuppression, then I think you could call [this] a functional cure. tyccmoa tljtmkr iyje duuth ovijpb nzw tpm zzenc tuerd sqoqpf